{
  "id": 17928292,
  "title": "Selective binders of a cotranslational folding intermediate",
  "url": "https://urgent.news/2026/11/02/selective-binders-of-a-cotranslational-folding-intermediate",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-02T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763055v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Drug discovery efforts typically target mature, folded proteins, primarily to inhibit their function or induce their degradation. An alternative strategy would be to target incompletely folded states that are transiently populated during protein biogenesis, but whether these states contain druggable pockets was unclear. Here, we used an mRNA display approach to discover cyclic peptides that…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}