{
  "id": 17928287,
  "title": "Revamped transposon-induced hepatocellular carcinoma model reveals deep similarities of cancer-driver landscapes across mice and humans",
  "url": "https://urgent.news/2026/11/02/revamped-transposon-induced-hepatocellular-carcinoma-model-reveals",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-11-02T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763279v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Genome-scale cancer-driver discovery is limited by statistical uncertainty in driver calling and by experimental constraints on mutations available for selection. We developed 3xfOnc3 - a three-frame Sleeping Beauty (SB) mutagenesis system designed to broaden functional perturbations and reduce integration biases of traditional SB screens - and tested it in vivo in mouse liver. Within 12 months,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}