{
  "id": 17928281,
  "title": "The DNA demethylase TET1 recognises chromatin via nucleosome engagement of its N-terminal region",
  "url": "https://urgent.news/2026/11/02/the-dna-demethylase-tet1-recognises-chromatin-via-nucleosome",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-02T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763349v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "TET1 is a DNA demethylase critical for mammalian embryonic development, yet how it is recruited to its chromatin substrate remains poorly understood. Here we identify a previously uncharacterized N-terminal region of TET1 that directly binds nucleosomes and promotes chromatin binding in mouse embryonic stem cells. Robust chromatin association was evidenced by fluorescence recovery after…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}