{
  "id": 17832925,
  "title": "Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling",
  "url": "https://urgent.news/2026/11/02/long-pde4d-degradation-attenuates-left-ventricular-cardiomyocyte",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-02T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.30.762532v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Spatial compartmentalisation enables cyclic AMP (cAMP) to regulate distinct cellular functions, yet selectively targeting disease-associated signalling remains challenging. Phosphodiesterases constrain local cAMP responses, but conventional inhibitors offer limited isoform selectivity. Here we investigate whether targeted degradation of long phosphodiesterase-4D (PDE4D) isoforms can suppress…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}