{
  "id": 17578363,
  "title": "Impact of RNA modification and IL-12 boosts on mRNA-LNP vaccine-elicited CD8+ T cell responses",
  "url": "https://urgent.news/2026/11/01/impact-of-rna-modification-and-il-12-boosts-on-mrna-lnp-vaccine",
  "topic": "science",
  "section": "Science",
  "published": "2026-11-01T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.26.761945v1?rss=1"
  },
  "original_language": "en",
  "account": "To create effective HIV-1 vaccines, strategies are needed to stimulate both CD8+ T cell and neutralizing antibody responses. Nucleoside-modified mRNA-LNP vaccines produce stronger antibody reactions than unmodified mRNA-LNP vaccines, whereas unmodified mRNA is commonly used for CD8+ T cell-inducing vaccines. Researchers investigated the impact of varying ratios of unmodified versus modified mRNA expressing a SIV conserved-region CD8+ T cell immunogen, when combined with IL-12-encoding mRNA-LNP during boosting, on CD8+ T cell and humoral responses in non-human primates. They also compared these results to ChAdOx1-primed controls.\n\nSerial priming and boosting with unmodified mRNA generated stronger, more CD8-biased T cell responses compared to fully-modified mRNA. These boosted responses persisted over time after IL-12-encoding mRNA boosts. Adding 30% nucleoside-modified mRNA increased antibody levels, indicating that a mixed-composition vaccine may have additional advantages.",
  "summary": "Development of effective HIV-1 vaccines requires strategies for inducing both CD8+ T cell and neutralizing antibody responses. Nucleoside-modified mRNA-lipid-nanoparticles (LNP) induce more potent antibody responses than unmodified mRNA-LNP vaccines, while unmodified mRNA is typically employed for CD8+ T cell-inducing vaccines. Here, we compared the abilities of differing ratios of unmodified…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}