{
  "id": 1752695,
  "title": "Perturb-ME: Scalable mechanism discovery from phenotype-enriched genome-wide screens",
  "url": "https://urgent.news/2026/08/18/perturb-me-scalable-mechanism-discovery-from-phenotype-enriched",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.17.745330v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Perturb-seq enables pooled genetic screens with rich single-cell profiling readouts, but genome-scale profiling remains costly and may not be associated with other established functional characteristics. Moreover, as screens grow in size and complexity, interpreting the resulting data comprehensively is challenging and slow. Here, we introduce Perturb-seq with Marker Enrichment (Perturb-ME),…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}