{
  "id": 1745036,
  "title": "NMDA receptor hypofunction on GABAergic interneurons results in input-specific Excitatory/Inhibitory imbalance in pyramidal neurons of medial prefrontal cortex.",
  "url": "https://urgent.news/2026/08/18/nmda-receptor-hypofunction-on-gabaergic-interneurons-results-in-input",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.12.744479v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Excitation/inhibition (E/I) balance in cortical circuits is typically treated as a global neuronal property, yet pyramidal neurons integrate synaptic inputs from anatomically distinct afferent pathways whose regulation may not be uniform. Using a mouse model with early postnatal NMDA receptor (NMDAR) ablation from corticolimbic GABAergic interneurons associated E/I dysfunction, we tested whether…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}