{
  "id": 1729578,
  "title": "Compact type II-C Cas9 nucleases with expanded PAM access and high fidelity for therapeutic genome editing",
  "url": "https://urgent.news/2026/08/18/compact-type-ii-c-cas9-nucleases-with-expanded-pam-access-and-high",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.17.745178v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Compact type II-C Cas9 nucleases are attractive for therapeutic genome editing because their small size enables packaging into adeno-associated viral (AAV) vectors, and their extended protospacer-adjacent motifs (PAMs) reduce off-target cleavage while expanding targeting scope. Yet characterized type II-C orthologs have edited mammalian cells far less efficiently than the canonical SpCas9. Here,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}