{
  "id": 17258220,
  "title": "KIF1A-driven entry of degradative lysosomes into the axon is developmentally regulated by the microtubule environment at the axon initial segment",
  "url": "https://urgent.news/2026/10/30/kif1a-driven-entry-of-degradative-lysosomes-into-the-axon-is",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-30T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762862v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Neuronal function requires precise transport of lysosomal vesicles along highly polarized processes, yet how this trafficking is spatially and developmentally regulated remains poorly understood. Here, we show that the neuronally enriched kinesin-3 motor KIF1A is required for dendritic and axonal localization of lysosomal vesicles in both immature and mature rat hippocampal neurons. Remarkably,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}