{
  "id": 17250322,
  "title": "Mapping chromothripsis across human cancer cell lines reveals genome evolution and therapeutic vulnerabilities",
  "url": "https://urgent.news/2026/10/30/mapping-chromothripsis-across-human-cancer-cell-lines-reveals-genome",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-30T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763015v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Chromothripsis is a catastrophic chromosomal rearrangement found in ~40% of primary tumors, yet its landscape in cancer cell lines (CCLs) remains uncharacterized. To address this gap, we developed a pipeline to detect chromothripsis-like events from copy-number data alone, and mapped their occurrence across 1,646 human CCLs. Chromothripsis patterns were broadly conserved between primary tumors…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}