{
  "id": 17234702,
  "title": "Somatic variant detection using an individual-specific pangenome reference: a case study of a pediatric acute myeloid leukemia patient",
  "url": "https://urgent.news/2026/10/30/somatic-variant-detection-using-an-individual-specific-pangenome",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-30T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.27.756267v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background: Reference bias can cause false or missed somatic variant calls, also in clinically relevant genes. Pangenomes aim to reduce this bias, but evidence of their diagnostic benefit is lacking. We tested how an individual-specific pangenome affects somatic variant calling in bulk samples and single cells. Results: We built an individual-specific pangenome from Nanopore assemblies of normal…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}