{
  "id": 17234693,
  "title": "Protein co-scientist aided simulations of the structural and functional impact of O-GlcNAc Transferase TPR domain deletions and amino acid substitutions associated with X-Linked Intellectual Disability",
  "url": "https://urgent.news/2026/10/30/protein-co-scientist-aided-simulations-of-the-structural-and",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-30T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762748v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "O-GlcNAc transferase (OGT) is an essential glycosyltransferase that regulates cellular processes through the addition of O-linked {beta}-N-acetyglucosamine (O-GlcNAc) to target proteins. Substrate recognition and protein-protein interactions are mediated by the tetratricopeptide repeat (TPR) domain, yet the contributions of individual TPR repeats to structural stability and function remain poorly…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}