{
  "id": 17131842,
  "title": "Tumour architecture inverts ARNT-dependent growth regulation and reveals CPE-mediated spheroid expansion in luminal breast cancer",
  "url": "https://urgent.news/2026/10/29/tumour-architecture-inverts-arnt-dependent-growth-regulation-and",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-29T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.27.761882v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Tumour architecture profoundly influences cancer cell behaviour, yet functional genomic studies predominantly rely on two-dimensional (2D) cultures. Here, we performed parallel chromosome 1q focused CRISPR screens in matched 2D monolayers and three-dimensional (3D) spheroid cultures of luminal breast cancer cells, which revealed ARNT as a prominent architecture-dependent fitness regulator. ARNT…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}