{
  "id": 17131841,
  "title": "Lineage-mixed neurodevelopmental programs in pediatric sarcomas nominate tumor-selective surface antigen pairs.",
  "url": "https://urgent.news/2026/10/29/lineage-mixed-neurodevelopmental-programs-in-pediatric-sarcomas",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-29T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.28.762504v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Pediatric solid tumors have low mutational burden, frequent oncogenic gene fusions, and developmental origins in arrested progenitor cells. Single-cell RNA-seq (scRNA-seq) could represent an ideal tool to assess whether these convergent biological features yield shared therapeutic vulnerabilities. However, while existing tools can extract gene expression programs for pan-tumor single-cell data,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}