{
  "id": 17131831,
  "title": "Targeted proteomics informed by long-read RNA-sequencing reveals protein isoform expression associated with bone mineral density",
  "url": "https://urgent.news/2026/10/29/targeted-proteomics-informed-by-long-read-rna-sequencing-reveals",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-29T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.28.759629v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The expanding catalog of sQTLs from projects like GTEx has established that genetic risk for complex traits is frequently mediated through RNA splicing. Yet it is generally unknown whether disease-associated splice events produce stable, distinct protein isoforms and whether they are functionally consequent. Even the deepest shotgun proteomics efforts only capture a minority of annotated splice…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}