{
  "id": 17106726,
  "title": "Immunogenicity and safety of Institut Pasteur du Cambodge (IPC) and updated Thai Red Cross (UTRC) intradermal rabies vaccine regimens among healthy adults in India: A phase 4, open label, equivalence randomised controlled trial",
  "url": "https://urgent.news/2026/10/29/immunogenicity-and-safety-of-institut-pasteur-du-cambodge-ipc-and",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-29T14:00:00.000Z",
  "source": {
    "name": "PLOS Medicine",
    "slug": "plos-medicine",
    "url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005079"
  },
  "original_language": "en",
  "account": "A recent study examined the effectiveness and safety of two intradermal rabies vaccine regimens among healthy adults in India. The research compared the IPC and UTRC vaccines, administered intradermally over different periods, and the findings were published in a phase 4, open-label, equivalence randomized controlled trial. Both vaccines, Purified Chick Embryo Cell vaccine (PCECV) and Purified Vero Cell Rabies vaccine (PVRV), were used in the study, with the UTRC regimen requiring a longer four-week course compared to the IPC regimen's one-week schedule. The primary objective of the trial was to determine if the IPC regimen's immunogenicity matched that of the UTRC regimen. A total of 400 participants were randomly assigned to receive one of the four vaccine regimens. By the 42nd day post-immunization, the IPC regimen's geometric mean concentration ratio was 0.59 for PCECV and 0.76 for PVRV, which did not meet the equivalence criterion set at 0.72 to 1.04. Despite this, all participants in all four groups achieved rabies virus neutralizing antibody (RVNA) titres of at least 0.5 IU/mL within the study period, indicating seroconversion. Adverse events were generally mild and similar across the different vaccine regimens. However, the study had limitations, including a quarter of participants exhibiting baseline RVNA titres of at least 0.5 IU/mL, suggesting potential unrecognized prior exposure to rabies. Therefore, while the IPC regimen did not match the UTRC regimen's immunogenicity, both vaccines effectively induced seroconversion. Policy decisions on updating the UTRC regimen should consider these immunogenicity results alongside factors such as compliance, cost, and vaccine availability.",
  "summary": "by Jeromie Wesley Vivian Thangaraj, Padinjaremattathil Thankappan Ullas, Balaji Dagadu More, Lokesh Shanmugam, Saravanakumar Velusamy, Dinesh Gopal, Subashri Ramamoorthy, Kanagasabai Kaliaperumal, Mugunthan N. M, Sandhya Arunachalam, Ramaprabha Ramachandran, Gopinath Ramakrishnan, Suresh Arunachalam, Vijay Vidhyakar J. M, Ganeshnee Anthuvan Valli, Siddharth Pugalendhi, Sabarinathan Ramasamy,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}