{
  "id": 17077941,
  "title": "Joint localization and testing reveals spatial context of differential expression",
  "url": "https://urgent.news/2026/10/29/joint-localization-and-testing-reveals-spatial-context-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-29T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.28.758685v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Multi-subject spatial transcriptomics is increasingly used to identify molecular differences across individuals and conditions while resolving where in tissue those differences occur. Yet subject-level differential expression (DE) analyses commonly require spatial regions to be specified in advance, separating localization from testing. Here we present SpaceDX, a framework that uses gene-specific…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}