{
  "id": 17053708,
  "title": "A mechanistic classification of GNAO1 mutations links Gβ γ sequestration to hyperkinetic disease and treatment response",
  "url": "https://urgent.news/2026/10/29/a-mechanistic-classification-of-gnao1-mutations-links-g-sequestration",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-29T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761540v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Go is the most prevalent G protein subunit in the brain and is critical for signal transduction through G protein-coupled receptors. Mutations in the gene encoding Go (GNAO1) cause a rare neurodevelopmental disorder with involuntary movements (NEDIM) and, in some patients, developmental and epileptic encephalopathy (DEE). Here, we integrate human genetic analysis with cellular assays to define…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}