{
  "id": 17031168,
  "title": "Scalable variant-to-function screens using prime editing perturb-seq",
  "url": "https://urgent.news/2026/10/28/scalable-variant-to-function-screens-using-prime-editing-perturb-seq",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.28.762453v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Linking genetic variants to their functional consequences at scale remains a major challenge in human genetics. Perturb-seq is limited in the variants it can install, while prime editing has largely been restricted to simpler mechanistic readouts. Here, we introduce prime editing perturb-seq (PEP-seq), which links programmed mutations to transcriptomic states. We designed 2,164 prime editing…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}