{
  "id": 16959028,
  "title": "Transient Splicing-Associated Isoform Remodeling Defines Early MAPKi Resistance Adaptation in Melanoma",
  "url": "https://urgent.news/2026/10/28/transient-splicing-associated-isoform-remodeling-defines-early-mapki",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.26.761932v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "A long-standing question in targeted therapy resistance is how tumor cells rapidly enter drug-tolerant states before stable resistance emerges. In BRAF-mutant melanoma, early adaptation to MAPK inhibitor (MAPKi) therapy is accompanied by profound phenotypic plasticity, yet the molecular mechanisms that enable this transition remain poorly understood. Here, we show that MAPKi adaptation is…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}