{
  "id": 16959021,
  "title": "Core Coefficient quantifies transcription-factor functional dominance for therapeutic target selection",
  "url": "https://urgent.news/2026/10/28/core-coefficient-quantifies-transcription-factor-functional-dominance",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.27.760230v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Transcription factors (TFs) operate in regulatory networks to control gene expression. The functional importance or leverage of a TF depends on the specific regulatory network in which it operates. Commonly used measurements of TF biology do not quantify the functional importance of TFs in these networks, which makes target selection for therapeutic intervention suboptimal. We developed the Core…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}