{
  "id": 16951401,
  "title": "Oncogenic PIK3CA mutations cause lineage-selective niche corruption",
  "url": "https://urgent.news/2026/10/28/oncogenic-pik3ca-mutations-cause-lineage-selective-niche-corruption",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.26.761693v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Activating PIK3CA mutations occur in cancer and also non-malignant overgrowth disorders, in which marked lineage-selectivity of pathology is characteristic. Yet the basis of such context-dependent effects remains poorly understood. Here, by combining patient-derived and CRISPR-engineered iPSC models of vascular development with time-resolved, single-cell signalling and transcriptomic analyses, we…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}