{
  "id": 16951387,
  "title": "A cell-free system for mitotically-stimulated TMEJ",
  "url": "https://urgent.news/2026/10/28/a-cell-free-system-for-mitotically-stimulated-tmej",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.26.762058v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Double-stranded DNA breaks (DSBs) are cytotoxic and must be repaired to avoid cell death or mutagenesis. DSBs that form in the S or G2 phases of the cell cycle undergo end resection, creating substrates for homologous recombination (HR) and alternative end joining pathways. Theta-mediated end joining (TMEJ) is a DNA polymerase {theta} (Pol {theta}) dependent repair pathway that joins resected DSB…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}