{
  "id": 16912109,
  "title": "Mitochondrial folate transport becomes essential in serine/glycine-starved triple-negative breast cancer",
  "url": "https://urgent.news/2026/10/28/mitochondrial-folate-transport-becomes-essential-in-serine-glycine",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.26.756950v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Triple-negative breast cancers frequently upregulate the serine synthesis pathway, rendering them resistant to exogenous serine/glycine restriction. To identify vulnerabilities that emerge under serine/glycine limitation, we performed a metabolic CRISPR dropout screen in resistant TNBC cells and identified mitochondrial folate metabolism as a critical dependency. Loss of the folate transporter…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}