{
  "id": 16904132,
  "title": "The Aging Brain Matrix: Cross-Species Evidence Linking FREM3 to Brain and Cognitive Aging",
  "url": "https://urgent.news/2026/10/28/the-aging-brain-matrix-cross-species-evidence-linking-frem3-to-brain",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.27.762265v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The human extracellular-matrix-related FREM3 gene is strongly age-dependent, enriched in age-sensitive excitatory long-range-projecting neurons, and implicated in neurodegenerative diseases. To establish the first translationally relevant causal evidence for the role of FREM3 in brain structure and cognition, we developed an excitatory-neuron-specific Frem3 conditional knockout mouse model…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}