{
  "id": 16880726,
  "title": "Compact CRISPR-based genetic circuitry using a miniature genome-integrated Cas12m protein",
  "url": "https://urgent.news/2026/10/28/compact-crispr-based-genetic-circuitry-using-a-miniature-genome",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.26.761838v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "CRISPR-Cas systems can be repurposed as programmable transcription factors, offering a virtually limitless supply of orthogonal regulators for building genetic circuits. However, the commonly used dCas9-based systems place a heavy burden on the host, are slow to release their target, and suffer interference between guide RNAs as they compete for a shared pool of Cas protein. Here we show that…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}