{
  "id": 16801344,
  "title": "IL-27 Reduces Cell-Surface LDLR in Human Macrophages and Restricts VSV-G-Pseudotyped HIV infection",
  "url": "https://urgent.news/2026/10/27/il-27-reduces-cell-surface-ldlr-in-human-macrophages-and-restricts",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-27T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.761012v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Low-density lipoprotein receptor (LDLR) is a major cellular receptor for vesicular stomatitis virus glycoprotein (VSV-G), which is widely used to pseudo-type viral vectors. We previously showed that IL-27 suppresses infection by VSV-G-pseudotyped HIV encoding luciferase (VSV-G-HIVLuc) in macrophages; although IL-27 induced multiple anti-virus genes in cell, the underlying mechanism of VSVG-HIVLuc…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}