{
  "id": 16777954,
  "title": "Human prion proteins and mutants through the lens of systems biology",
  "url": "https://urgent.news/2026/10/27/human-prion-proteins-and-mutants-through-the-lens-of-systems-biology",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-27T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761545v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Autocatalytic conformational changes of cellular prion proteins (PrPC) to the {beta}-sheet-enriched scrapie isoform (PrPSC) drive prion diseases, yet the precise molecular mechanisms remain unclear. To address this, we employ a multi-pronged framework integrating network-theoretic analyses, molecular dynamics (MD) simulations, and experimental validation to characterize critical residues…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}