{
  "id": 16775793,
  "title": "A GCN1-independent activator of the kinase GCN2",
  "url": "https://urgent.news/2026/10/27/a-gcn1-independent-activator-of-the-kinase-gcn2",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-27T00:00:00.000Z",
  "source": {
    "name": "eLife",
    "slug": "elife",
    "url": "https://elifesciences.org/articles/108590"
  },
  "original_language": "en",
  "account": null,
  "summary": "Mutations of EIF2AK4 , which encodes the eIF2α kinase GCN2, cause a severe inherited form of pulmonary hypertension called pulmonary veno-occlusive disease (PVOD). Some pathogenic variants of GCN2 are amenable to pharmacological reactivation by low concentrations of ATP pocket-binding inhibitors. Kinase inhibition at modestly elevated concentrations limits the clinical utility of these drugs…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}