{
  "id": 16753811,
  "title": "In Silico Design and Evaluation of CRISPR Cytosine Base Editing Strategy for Potential Correction of the ASPA Variant Associated with Canavan Disease",
  "url": "https://urgent.news/2026/10/27/in-silico-design-and-evaluation-of-crispr-cytosine-base-editing",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-27T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761534v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "**Background** Canavan disease is a rare autosomal recessive neurodegenerative leukodystrophy caused by pathogenic variants in the ASPA gene, for which effective molecularly targeted therapies remain limited. The NM_000049.4:c.691T>C (p.Tyr231His) variant introduces a pathogenic C-G base pair that is potentially amenable to correction using cytosine base editing (CBE). This study aimed to design…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}