{
  "id": 16753808,
  "title": "Interactome-based deep learning and path-level decomposition reveal TGFβ-IFNα competition in MASH",
  "url": "https://urgent.news/2026/10/27/interactome-based-deep-learning-and-path-level-decomposition-reveal",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-27T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761530v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Dysregulated signaling drives Metabolic Dysfunction-Associated Steatohepatitis (MASH) through a complex crosstalk between pro- and anti-fibrotic cues. We previously observed potential competition between IFN-mediated JAK-STAT signaling and TGF{beta} in modulating MASH fibrosis, but the precise mechanism of that competition, and whether it can act directly on hepatocytes, is yet unknown. We used…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}