{
  "id": 16679713,
  "title": "TCF21 loss identifies a conserved inflammation-associated fibroblast state across Crohn's disease and ulcerative colitis",
  "url": "https://urgent.news/2026/10/26/tcf21-loss-identifies-a-conserved-inflammation-associated-fibroblast",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-26T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760764v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background and Aims: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are associated with stromal remodeling; however, the fibroblast states that contribute to chronic inflammation remain incompletely defined. We aimed to identify conserved pathogenic fibroblast programs across CD and UC and determine whether these states are linked to loss of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}