{
  "id": 16558283,
  "title": "Evaluating the added value of sequence models in noncoding RNA assays: a baseline-aware framework",
  "url": "https://urgent.news/2026/10/25/evaluating-the-added-value-of-sequence-models-in-noncoding-rna-assays",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-25T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.760090v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Sequence models are evaluated against non-coding RNA assay read-outs, but prediction alone does not show what their features add to an explicit baseline. We estimated model-added-last changes in AUROC for lncRNA labels and cross-validated Spearman correlation for miRNA repression, fixing members and chromosome folds across available sources. In cross-cell CRISPRi (n = 2961), AlphaGenome increased…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}