{
  "id": 16551397,
  "title": "Protein Folding Interference Enables Selective Cyclin D1 Degradation",
  "url": "https://urgent.news/2026/10/25/protein-folding-interference-enables-selective-cyclin-d1-degradation",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-25T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.760876v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Cyclin D1 is a central regulator of cell-cycle progression and a compelling therapeutic target in cancer, yet its non-enzymatic function, limited ligandability, and rapid turnover have hindered direct pharmacological intervention. Here we show that these limitations can be overcome by targeting a transient conformational state populated during protein folding. Computational reconstruction of the…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}