{
  "id": 16426218,
  "title": "Astrocytic ablation of truncated TrkB receptors reduces amyloid plaques and prevents synaptic loss in 5xFAD mice",
  "url": "https://urgent.news/2026/10/24/astrocytic-ablation-of-truncated-trkb-receptors-reduces-amyloid",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.20.760443v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Brain-derived neurotrophic factor (BDNF) is essential for nervous system development and function and exerts its effects primarily through the tropomyosin receptor kinase B (TrkB). The Ntrk2 gene encodes a full-length receptor (TrkB.FL) and two truncated isoforms (TrkB.T1 and TrkB.T2, collectively TrkB.T) that lack the intracellular tyrosine kinase domain. TrkB.T is expressed predominantly in…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}