{
  "id": 16379756,
  "title": "Advanced age does not limit the benefits of sodium-glucose cotransporter 2 inhibitors in chronic kidney disease",
  "url": "https://urgent.news/2026/10/24/advanced-age-does-not-limit-the-benefits-of-sodium-glucose",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-24T22:30:01.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-10-advanced-age-limit-benefits-sodium.html"
  },
  "original_language": "en",
  "account": "A recent study analyzing electronic health records data on 10,076 adults aged 80 years or older with chronic kidney disease (CKD) reveals that SGLT2 inhibitor therapy, typically used to manage diabetes and hypertension, may offer significant benefits to very elderly patients with CKD. The research, set to be presented at ASN Kidney Week 2026, indicates that initiating SGLT2 inhibitor treatment results in an 18% reduction in all-cause mortality and a 22% decrease in major adverse kidney events over a two-year follow-up period.\n\nHowever, the study also highlights potential risks associated with SGLT2 inhibitors in this demographic. While overall major cardiovascular event risk remains unchanged, there is an increased likelihood of myocardial infarction, acute heart failure, and acute kidney injury. These findings underscore the need for a thorough individualized risk-benefit assessment and close clinical monitoring in very elderly CKD patients before starting SGLT2 inhibitor therapy.",
  "summary": "New research uncovers the potential benefits and risks of sodium-glucose cotransporter 2 (SGLT2) inhibitors for adults aged 80 years or older with chronic kidney disease (CKD). The findings will be presented at ASN Kidney Week 2026, Oct. 22–25.",
  "key_points": [
    "SGLT2 inhibitors benefit CKD patients aged 80+, reducing mortality by 18%",
    "Major adverse kidney events decrease by 22% over two-year period",
    "Increased risk of myocardial infarction, heart failure, and kidney injury"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}