{
  "id": 163696,
  "title": "Explainable HGT-based framework for predicting human dark kinase protein-pathway associations by leveraging BERT-based embeddings and WGAN-GP",
  "url": "https://urgent.news/2026/08/04/explainable-hgt-based-framework-for-predicting-human-dark-kinase",
  "topic": "ai",
  "section": "AI",
  "published": "2026-08-04T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.07.30.741784v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Discovery of pathway associations and druggability can leverage underutililized dark kinase genes for treating complex diseases (proven for cancer and neurodegeneration), boosted with computational methods. Herein, we employ BERT-based embeddings of proteins and pathways (refined via two-stage transformer and heterogeneous graph transformer) and protein-protein and protein-pathway associations-…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}