{
  "id": 16331041,
  "title": "CDKL5 deficiency alters cell subtype-specific molecular programmes and intercellular signalling in the mouse hippocampus",
  "url": "https://urgent.news/2026/10/24/cdkl5-deficiency-alters-cell-subtype-specific-molecular-programmes",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.760890v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental condition characterised by epilepsy, intellectual disability, and motor dysfunction. Loss of CDKL5 leads to altered synapse development, excitatory-inhibitory imbalances and glial changes, but the underlying molecular mechanisms remain incompletely understood, particularly at the level of individual brain cell subtypes. Here, we…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}