{
  "id": 16331040,
  "title": "Prevention of prion disease symptoms in mice with deep PrP lowering",
  "url": "https://urgent.news/2026/10/24/prevention-of-prion-disease-symptoms-in-mice-with-deep-prp-lowering",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.761034v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "PrP lowering slows prion disease in animal models, but prevention of symptoms by a therapeutic has never been demonstrated. A highly potent PrP-lowering C16-conjugated siRNA delivered into the cerebrospinal fluid (CSF) of mice lowers PrP to 12% residual in whole brain hemispheres. Early chronic treatment keeps prion-infected animals free from symptoms through 500 days post-inoculation,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}