{
  "id": 16331031,
  "title": "Interaction with complement factor C1q can contribute to and improve monoclonal antibody-mediated protection against lethal HSV-1 challenge",
  "url": "https://urgent.news/2026/10/24/interaction-with-complement-factor-c1q-can-contribute-to-and-improve",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.19.760222v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Herpes simplex virus (HSV) has extensive strategies to evade host defense, including mechanisms that limit clearance by the complement cascade. Using Fc engineering, we incorporated a complement-enhancing (E430G, EG) or a complement-abrogating mutation (K322A, KA) to a panel of glycoprotein D- and glycoprotein B-specific monoclonal antibodies (mAbs) to assess the role of complement-driven…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}