{
  "id": 16281730,
  "title": "Exploring the role of local sequence context on patterns of germline mutation",
  "url": "https://urgent.news/2026/10/23/exploring-the-role-of-local-sequence-context-on-patterns-of-germline",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.20.760577v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Germline mutations occur at a non-uniform rate across the genome. While the influence of neighboring nucleotides is well known and accounted for in mutation models, the effective range of these flanking influences and the extent of their higher-order interactions remain insufficiently understood. Here, we leverage millions of singleton variants from the 1000 Genomes Project as a proxy for…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}