{
  "id": 16275079,
  "title": "Relaxed evolutionary constraints on mitochondrial electron-transfer-associated variants in human cancers",
  "url": "https://urgent.news/2026/10/23/relaxed-evolutionary-constraints-on-mitochondrial-electron-transfer",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760641v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Mitochondrial electron transfer depends on quantum-mechanical coupling between redox cofactors, but its evolutionary constraints in cancer remain unclear. We combined the human complex III cryo-EM structure, Pathways calculations and Marcus theory to predict how missense substitutions in mitochondrial cytochrome b (MT-CYB), which coordinates the Q-cycle haem centres, affect electron-transfer…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}