{
  "id": 16233267,
  "title": "MULTIVALENT ACE2 ENGAGEMENT ACTIVATES PIEZO1-SPHINGOMYELINASE SIGNALING IN SARS-COV-2 SPIKE-MEDIATED CELL-CELL FUSION",
  "url": "https://urgent.news/2026/10/23/multivalent-ace2-engagement-activates-piezo1-sphingomyelinase",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.761047v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "SARS CoV 2 Spike not only fuses the viral envelope with host membranes to deliver viral RNA but also drives syncytium formation, a process that may contribute to viral spread and pulmonary pathology. Although the conformational transitions in Spike triggered by ACE2 engagement are well characterized, the host cell signaling events initiated by Spike-ACE2 interactions remain less understood. Here,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}