{
  "id": 16233264,
  "title": "Disease-associated MYH11 tail variants disrupt vascular smooth muscle myosin II filament dynamics and cell mechanics",
  "url": "https://urgent.news/2026/10/23/disease-associated-myh11-tail-variants-disrupt-vascular-smooth-muscle",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.760788v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Smooth muscle myosin II (SMII), encoded by MYH11, is the principal motor driving vascular smooth muscle cell (VSMC) contraction. How disease-associated MYH11 variants alter SMII behavior in living cells remains poorly understood. We directly visualized two human MYH11 tail variants in VSMCs: pathogenic K1256del and a variant of uncertain significance A1839V, identified in a patient with severe…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}