{
  "id": 16233263,
  "title": "The Desmoplakin Hinge Domain Confers a Reversible Conformational Change in Response to Acute External Force",
  "url": "https://urgent.news/2026/10/23/the-desmoplakin-hinge-domain-confers-a-reversible-conformational",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.760798v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Desmosomes provide mechanical integrity to tissues that experience strain, yet how mechanical force is sensed and distributed within the desmosomal plaque remains poorly understood. Here we identify the hinge within the desmoplakin (DP) head domain is required for repositioning the DP tail in response to acute uniaxial mechanical stretch. This repositioning occurs within 30 seconds of applied…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}