{
  "id": 16220141,
  "title": "STAT+: Patient dies in Bristol Myers Squibb autoimmune CAR-T trial",
  "url": "https://urgent.news/2026/10/23/stat-patient-dies-in-bristol-myers-squibb-autoimmune-car-t-trial",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-23T18:55:12.000Z",
  "source": {
    "name": "STAT News",
    "slug": "stat-news",
    "url": "https://www.statnews.com/2026/10/23/bristol-myers-squibb-car-t-therapy-autoimmune-trial-death/"
  },
  "original_language": "en",
  "account": "Bristol Myers Squibb disclosed on Friday that a patient had tragically passed away following the administration of its investigational CAR-T therapy in an early autoimmune trial, further deepening concerns regarding the safety of this rapidly expanding field of research. The Phase 1 trial, which assessed the therapy's efficacy in multiple sclerosis, a debilitating condition characterized by muscle weakness and profound fatigue, witnessed the patient developing severe motor symptoms that failed to abate even with the administration of conventional autoimmune treatments. In an attempt to mitigate the situation, the patient was administered a robust immunosuppressant; however, this course of action resulted in the unfortunate development of septic pneumonia, ultimately leading to the patient's demise, as stated in the pharmaceutical company's press release. This incident is emblematic of a concerning trend in CAR-T autoimmune trials, as safety events have started to surface recently. In September, Bristol Myers Squibb itself acknowledged the need to pause its CAR-T therapy studies after observing \"transient and reversible inflammatory events during routine study surveillance,\" following questions raised by analysts and reporters. Simultaneously, Novartis, also on the back foot due to similar concerns, disclosed the untimely deaths of three patients in its CAR-T autoimmune studies, who had succumbed to an overactive immune system after experiencing such conditions.",
  "summary": "Where should the safety bar be for studies investigating CAR-T therapies for autoimmune conditions?",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Endpoints News",
        "title": "Bristol Myers reveals autoimmune CAR-T trial death, explains summertime pause",
        "url": "https://urgent.news/2026/10/23/bristol-myers-reveals-autoimmune-car-t-trial-death-explains",
        "published": "2026-10-23T14:33:54.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}