{
  "id": 16113267,
  "title": "Semaglutide Increases Striatal Leptin Sensitivity, Impacting Dopaminergic Response to Cocaine",
  "url": "https://urgent.news/2026/10/22/semaglutide-increases-striatal-leptin-sensitivity-impacting",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759697v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "There is accumulating evidence that the GLP-1 analog, semaglutide, might effectively curb intake of cocaine via brain dopaminergic functioning, despite limited brain penetrance. However, there is currently no established mechanism elucidating how chronic semaglutide treatment regulates the dopaminergic response to cocaine. Cocaine is a highly addictive substance that produces rewarding effects…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}