{
  "id": 16089584,
  "title": "Proteins Circulating in Blood Linked to Future Risk of Prostate Cancer",
  "url": "https://urgent.news/2026/10/22/proteins-circulating-in-blood-linked-to-future-risk-of-prostate-cancer",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-22T18:22:49.000Z",
  "source": {
    "name": "GEN Biotechnology",
    "slug": "gen-biotechnology",
    "url": "https://www.genengnews.com/topics/cancer/proteins-circulating-in-blood-linked-to-future-risk-of-prostate-cancer/"
  },
  "original_language": "en",
  "account": "A recent large-scale study has identified proteins in the blood that may indicate a future risk of prostate cancer, including aggressive forms of the disease. Conducted by Oxford Population Health, the research involved over 2,500 men and found biological differences between those later diagnosed with prostate cancer and those who did not. The study, published in European Urology and presented at the American Society of Human Genetics (ASHG) Annual Meeting, could help guide future risk assessment efforts. Professor Karl Smith-Byrne, a co-senior author, explained that discovering proteins linked to known prostate cancer driver genes in blood collected years prior may provide new insights into the earliest stages of the disease. The findings suggest potential biological pathways that could be targeted to prevent aggressive prostate cancer. Among the proteins identified were GZMK, ANKRD1, and proteins associated with immune, adhesion, angiogenesis, and cancer driver-gene pathways. Twelve proteins were linked to prostate cancer diagnoses more than 15 years after the blood sample was collected, with one protein, ANKRD1, consistently associated with several serious forms of the disease. The study also found links between blood levels of certain proteins and aggressive prostate cancer diagnosed around a decade later, indicating biological changes associated with the future development of the disease. However, the proteins identified are not yet suitable for clinical use and further studies are needed to confirm their potential as risk markers.",
  "summary": "The results of a large prospective proteomic study have associated proteins linked with the immune system, cell adhesion, blood vessel formation, and known prostate cancer genes, to future risk of developing prostate cancer, including aggressive disease. The post Proteins Circulating in Blood Linked to Future Risk of Prostate Cancer appeared first on GEN - Genetic Engineering and Biotechnology…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Medical Xpress",
        "title": "Blood proteins could reveal clues to prostate cancer risk more than a decade before diagnosis",
        "url": "https://urgent.news/2026/10/21/blood-proteins-could-reveal-clues-to-prostate-cancer-risk-more-than-a",
        "published": "2026-10-21T18:30:01.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}