{
  "id": 16075973,
  "title": "'Molecular glue' stabilizes protein that inhibits development of non–small cell lung cancer and uterine cancer",
  "url": "https://urgent.news/2026/10/22/molecular-glue-stabilizes-protein-that-inhibits-development-of-non",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-22T17:20:07.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-10-molecular-stabilizes-protein-inhibits-nonsmall.html"
  },
  "original_language": "en",
  "account": "Molecular glue RPT04402 stabilizes tumor-suppressive protein PP2A, which inhibits development of non-small cell lung cancer and uterine cancer. This protein phosphatase 2A requires three proteins to bind for proper function and tumor suppression. When PP2A fails to assemble, it is common in lung, uterine, prostate and liver cancer. University of Michigan researchers found that targeting PP2A using RPT04402 can help treat non-small cell lung cancers with KRAS mutations, which are present in 30% of cases. Combining adagrasib or trametinib with RPT04402 delayed resistance and increased treatment effectiveness in mouse models. The team plans to start clinical trials to test this combination in various cancer types.",
  "summary": "Protein phosphatase 2A plays a central role in controlling many cell signaling pathways, which are frequently disrupted during tumor development and growth.",
  "key_points": [
    "RPT04402 stabilizes tumor-suppressive protein PP2A",
    "PP2A failure leads to cancer development in multiple types",
    "Combination therapy delays resistance and improves treatment"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}