{
  "id": 16067065,
  "title": "VO659, a CAG repeat-targeting antisense oligonucleotide, lowers multiple neurotoxic mutant huntingtin proteins in Huntington's disease",
  "url": "https://urgent.news/2026/10/22/vo659-a-cag-repeat-targeting-antisense-oligonucleotide-lowers",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.16.758452v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene, encoding an elongated polyglutamine stretch in the corresponding mutant HTT (mHTT) protein. HD pathogenesis is driven by multiple neurotoxic mHTT protein species, including HTT1a and repeat-associated non-AUG translation (RAN) proteins, which increase in expression as mutant CAG repeats lengthen due to…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Medical Xpress",
        "title": "New gene-editing approach shows promise in treating Huntington's disease in mice",
        "url": "https://urgent.news/2026/10/22/new-gene-editing-approach-shows-promise-in-treating-huntingtons",
        "published": "2026-10-22T19:40:06.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}